EXOSOMAL MIR-301A-3P FROM ESOPHAGEAL SQUAMOUS CELL CARCINOMA CELLS PROMOTES ANGIOGENESIS BY INDUCING M2 POLARIZATION OF MACROPHAGES VIA THE PTEN/PI3K/AKT SIGNALING PATHWAY

Abstract Background Growing evidence has indicated that tumor-associated macrophages (TAMs) promote tumor angiogenesis.However, the mechanisms underlying the pro-angiogenic switch of TAMs remains unclear.Here, we examined how exosomal miR-301a-3p secreted by esophageal squamous cell carcinoma (ESCC) cells triggers the pro-angiogenic switch of TAMs.

The human and bovine bacterial pathogen Streptococcus agalactiae (Group B Streptococcus, GBS) expresses a thick polysaccharide capsule that constitutes a major virulence factor and vaccine target.GBS can be classified into ten distinct serotypes differing in the chemical composition of their capsular polysaccharide.However, non-typeable strains tha

A strong earthquake with a magnitude of 7.5 occurred near the island of Paramushir (Kuril Islands) on 25 March 2020.It caused a weak tsunami in Kamchatka and the Kuril Islands.Earthquake and tsunami data from three DART buoys are discussed and compared with numerical simulations.It is shown that cashel tail bag the calculated and measured tsunami c

Optically active defects in silica have been studied for decades and are often indicators of network irregularities such as those that might result from optical or mechanical damage.They are well-known to be weak emitters and are usually present in relatively low concentration, thus precluding their use in a wide range of applications, including se